综上所述，IL-6是牙髓、尖周组织参与炎症反应的主要细胞因子之一，通过单核-巨噬细胞、成纤维细胞、血管内皮细胞等分泌，IL-6在局部组织中参与体液免疫和细胞免疫，发挥其多种生物学效应。

本研究为国家自然科学基金(39470752)资助课题

作者单位：西安第四军医大学口腔医学院　710032

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