综上可见，在PCNA 阳性细胞率高、细胞增殖旺盛的区域，PCD 阳性细胞也相应多，髁状突软骨增殖层及浅肥厚层软骨细胞不断增殖的同时通过PCD 可清除多余的细胞，控制着细胞数量，调节生长发育的速度。细胞增殖与PCD 的相互作用也协同参与关节腔、髁状突等结构的塑形。

作者单位：西安第四军医大学口腔医学院 710032

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